Since the beginning of Islam, interpretation of the Quran has been one of the important issues. Mawarannahr became one of the centers of Quranic studies, i.e. the science of interpretation (tafsir), in the Middle Ages. In general, the books of tafsir written in Mawarannahr are not taught only in Central Asia, but also in other famous religious educational institutions of the Islamic world, including Al-Azhar (Egypt), Dar al-Ulum (India and Pakistan), Islamic higher education and scientific research institutions (Saudi Arabia, Iraq, etc.). These valuable works, written in Arabic, have been published again and again. They have taken a firm place among the works that are in the focus of the worlds researchers. In the 9th century, muhaddiths such as Abd Ibn Humayd al-Keshi, Imam al-Bukhari, Imam al-Tirmidhi, Abu Abdullah al-Darimi started the tradition of writing naqli tafsir in Mawarannahr. In this article, the stages of emergence and development of the science of tafsir in Mawarannahr are scientifically analyzed. First of all, the emergence of the science of interpretation and its introduction into the region is discussed. The types of interpretation are touched upon. Tafsirs written by scholars of Mawarannahr and their specific aspects are revealed. Whether these commentaries have reached us or not, as well as information about their modern editions, is given.