Various regions throughout the globe have had detrimental consequences in tall multi-story buildings as a result of earthquakes, mostly owing to the presence of various abnormalities and badly planned constructions. A structure is said to be vertically irregular when there is an uneven distribution of stiffness, strength, and mass across the height of the building. The presence of hanging columns in an uneven structure significantly increases its irregularity, resulting in a discontinuous load path and a higher likelihood of collapse during an earthquake. The presence of a hanging column, caused by a discontinuity in the load path, compromises the structural integrity of the structure, resulting in reduced performance. The current research examines and analyses high-rise buildings with a regular construction and irregularities, both with and without a hanging column. An analysis has been conducted to examine the crucial placement of a hanging column in various positions around the peripheral columns of both regular and irregular buildings in zone V. The research examines the behaviour of high-rise buildings, namely those with regular and irregular vertical structures, that are ten stories tall and include hanging columns. The buildings are tested under earthquake stresses to observe their reaction. The different reaction parameters, including base shear, storey drift, node displacement, shear pressures, and bending moments, are analysed in the different models. The findings are compared to assess the impact of the presence of a hanging column in a structure.