The maritime economy has been and still is the trigger and main catalyst for the realistic development of powerful economies of the world. However, this natural endowment has not been effectively and efficiently managed; and converted into the magic wand for the realistic and people-oriented development of the coastal countries of the Gulf of Guinea region; that have been in self-rule for the past sixty years. The lackluster performance of the Gulf of Guinea maritime economy; has been blamed on activities of criminal gangs on the high seas of the region. The truth however is that, the GoG region is very unfortunate not have selfless and visionary leaders at the helms of affairs of the individual countries, that should direct all instruments of coercion in stamping out crimes and criminality in the maritime domain. The study focuses on how to make the best out of all the matrix of international collaborations and actions towards ensuring a safe, secure and prosperous GoG maritime domain. The study adopted qualitative method in generating data through secondary sources such as academic journals, books, policy reports, magazines and internet materials. The data was analyzed through descriptive and discourse methods.