Purpose: The Study aims to understand the challenges that college teachers face in maintaining a healthy work-life balance and identify the factors that contribute to job satisfaction or dissatisfaction among college teachers. To provide evidence-based recommendations to improve work-life balance and job satisfaction for college teachers, ultimately benefiting both teachers and students. By understanding these challenges and their potential solutions, the study can contribute to creating a more sustainable and fulfilling work environment for college teachers, which can ultimately lead to improved student outcomes. Methodology: A systematic review of was carried out on the existing literature of Work-life balance and Job satisfaction in search engines: PubMed, Google Scholars, and Scopus. The eligible articles completed a screening process using exclusion criteria prior to being analyzed for the conceptual framework of the study. Findings/Result: The review identified various factors, including personal, organizational, and familial, that influence the work-life balance of college teachers. The study identified several research gaps in the field of work-life balance and job satisfaction among college teachers. Originality/Value: The systematic review provided a distinct understanding of the balance between work and personal life, as well as the level of satisfaction experienced by college teachers. The study also identified a correlation between personal and family matters of college teachers, as well as multiple strategies for improving their work-life balance. By implementing these methods, college teachers can enhance their efficiency and achieve greater success, enabling them to deliver the utmost appropriate care to their students.