Clinical data on the use of pharmacopuncture with cerebrum compositum in the treatment of diabetic polyneuropathy (DPN) in patients aged 40 to 65 years with type 2 diabetes mellitus (DM) are presented. Pharmacopuncture was used 3 times a week on the distal parts of the lower extremities, the course of treatment was 10–15 procedures. The use of pharmacopuncture with Cerebrum Compositum of the indicated parameters in patients with DPN led to an improvement in clinical indicators of neuropathy and made it possible to increase the conductivity of peripheral nerves by 1.5–2 times from the initial values, which was confirmed by electroneuromyography data.