The article is devoted epidemiological features colorectal cancer in Andijan region . The growing increase in the incidence of colorectal cancer in the world, accompanied by high mortality, forces us to pay special attention to the diagnosis and treatment of precancerous diseases of the colon and rectum. The mortality rate for this disease ranks second among malignant neoplasms, despite the fact that colorectal cancer is classified as a group of cancer diseases that can be prevented with early and timely detection .