Sexual health is a critical aspect of adolescent development, and addressing sexual health concerns in adolescent girls requires a comprehensive and sensitive approach. Obstetric and gynecological (OBG) nurses play a crucial role in providing education, support, and care to adolescent girls navigating issues related to sexual health. This review article explores various sexual health concerns faced by adolescent girls and examines the role of OBG nurses in addressing these concerns. Topics covered include reproductive anatomy and physiology education, contraception counseling, sexually transmitted infection (STI) prevention, menstrual health management, and promoting healthy relationships. The article also discusses the importance of culturally sensitive care and the need for ongoing education and training for OBG nurses to effectively support adolescent girls in their sexual health journey.