Background: The recognition of any of the Dravya is through its Karma (Action). The karma is mainly explained with the help of Rasa panchaka in Ayurvedic science. Krimighna karma is one such karma which is responsible for the destruction of the krimi. Methods and materials: Swarasa, Aqueous- Methanolic and the chloroform extracts of Eranda Patra (Ricinus communis L.) was evaluated for its antimicrobial activity against Escherichia coli bacteria using Agar well diffusion method. Escherichia coli is a gram-negative bacterium residing in the colon which on pathological conditions will cause urinary tract infection, diarrhea, sepsis. As Eranda patra mainly acts on the urinary and digestive system and E. coli also affects the same system, the present work was undertaken to evaluate the Krimighna karma of Eranda patra against Escherichia coli. Observation and result: The zone of inhibition was observed using agar well diffusion antimicrobial screening method against Escherichia coli bacteria. Swarasa had shown maximum Zone of inhibition (12.66mm) for Escherichia coli bacteria when dispensed directly and moderate zone of inhibition (8mm) for swarasa with diluted concentrations after 48 hours of incubation period when compared to control group but not as that of standard group. Methanolic and the chloroform extract had shown moderate (5.5mm and 6mm) ZOI against Escherichia coli bacteria when compared to control but not as that of standard drug. The aqueous extract did not show any inhibition against the bacteria. These findings established the potential of swarasa and the extracts of Eranda patra as an effective antimicrobial agent against selected organisms. However, further studies are needed to evaluate active compounds and probable medicinal benefits in humans by clinical trials.