Rosella (Hibiscus sabdariffa L.) is a traditional remedy for hypertension due to its flavonoids that reduce blood viscosity. Its combination with crab shell offers a safer and more effective cholesterol-lowering alternative, primarily through anthocyanins. Dyslipidemia, a lipid metabolism disorder, involves elevated TC, LDL-C, TG, and decreased HDL-C, all linked to atherosclerosis. Management includes lifestyle changes and lipid-lowering drugs. Rosella extract effectively lowers LDL-C in rats, suggesting potential anti-dyslipidemia benefits. The study, conducted in January 2024, used an experimental Pre-test and Post-test group design. Sample size calculation determined a minimum of 4 rats per treatment group, weighing 180-200 grams and aged 2-4 months. The administration of Rosella flower extract (Hibiscus sabdariffa) in rats showed diverse responses in lipid profiles and liver function. The treatment groups exhibited increased total cholesterol and HDL, reduced LDL, and elevated total cholesterol and triglycerides. Statistical analysis confirmed significant differences between treatment groups, particularly in triglycerides. These findings also indicated a significant impact on liver function, with substantial differences in SGOT and SGPT levels. Further research is needed to explore the regulatory potential of Rosella extract on lipid metabolism and liver health.