The advantages and disadvantages of open (OR) and laparoscopic partial nephrectomy (LR) are described in detail in the literature. We undertook a study to compare all two methods according to the main indicators characterizing the surgical intervention and the patient’s stay in the hospital. 87 open and 34 laparoscopic partial kidney resections were performed . Patients with kidney cancer stage T1–2N0M0. The main indicators were assessed, including warm ischemia time (WTI), creatinine level , operation time, volume of blood loss, postoperative bed-day. The average duration of OR was lower than LR and RR (102.8, 162.7 and 143.3 min, respectively). The greatest VTI was in LR (16.6 min), and there was no significant difference between No RR and RR were obtained (14.5 and 12.9 min, respectively). Average volume of blood loss during RR and LR were significantly greater than with RR (332, 343 and 128 ml, respectively). The increase in creatinine was 28.6, 14.4 and 20.4% for OR, LR and RR, respectively. The longest postoperative bed-day was with OR, and the smallest with RR (13.0 and 9.0 days, respectively). For the first time, the results of a single comparison of three methods of kidney resection were obtained.