Plants that have the potential as analgesic-antipyretic compounds are mangosteen fruit (Garcinia mangostana L). Methanol extract from the peel of mangosteen fruit (Garcinia mangostana L.) contains several compounds, including saponins, alkaloids, flavonoids, triterpenoids, tannins, and polyphenols. The presence of flavonoids in mangosteen peel can inhibit prostaglandins, thus providing antipyretic effects. This study aims to evaluate the effectiveness of analgesic and antipyretic effects of methanol extract from mangosteen peel on Wistar rats. This research was conducted in January 2024 and utilized an experimental post-test-only Control Group Design. Data were analyzed using IBM SPSS 25, with normality tested using Shapiro-Wilk. The results indicate that mangosteen peel methanol extract contains various phytochemicals, including Alkaloids, Saponins, Flavonoids, Tannins, Steroids, and Terpenoids. The methanol extract demonstrates potential antipyretic and analgesic effects on male Wistar rats, especially at the highest dose (150 mg/kg body weight). The antipyretic effect was observed after 5 hours of administration, while the analgesic influence was evident simultaneously. Although the control group showed a significant decrease in body temperature 1 hour after treatment, the mangosteen peel methanol extract group III exhibited a more pronounced decrease at various times post-treatment than the control and standard groups. Hematological analysis revealed a reduction with an increase in the dose of mangosteen peel methanol extract. This potential makes the excerpt interesting for further research in drug development.