The present study is directed towards the hydroalcoholic extract of Clerodendrum infortunatum leaf categorized by antiasthmatic plants. Many herbal formulations are available for asthma but scientific validation and standardization is very difficult for this formulations. Phytochemical evaluation of the crude drugs such as ash value, extractive value were carried out and complies the limit given by quality standards of medicinal plants (ICMR). The fingerprint analysis was carried out for the Clerodendrum infortunatum, and compared the Rf values with gallic acid for the confirmation. The prepared hydroalcoholic extract of Clerodendrum infortunatum was subjected to determination of physical and chemical evaluations and the results complies as per the standards. The pharmacological findings concluded that the hydroalcoholic extract of Clerodendrum serratum could reverse asthmatic condition and reduced the total and differential WBC cell count in BALF, retained protein and MDA level in lung tissue, increased intact mast cells thus preventing its degranulation and mediators release. This Polyherbal hydroalcoholic extract of Clerodendrum serratum formulation is could be a promising new therapeutic approach for the treatment of clinical asthma.The stability studies and clinical trials to be carried out in future.