In this work, solvent evaporation was used to create nanosponges, which were then combined with Amphotericin B to create a gel. The Nanosponges formulations were made utilising the solvent evaporation process with PVA acting as a co-polymer and rate-retarders HP-β Cyclodextrin and HPMC K4M. Fourier Transform Infra-Red (FTIR) spectroscopy was used to determine the drugs compatibility with formulation ingredients. We looked at the drug entrapment effectiveness, production yield, and surface shape of nanosponges. Using scanning electron microscopy, the Nanosponges shape and surface morphology were investigated. Scanning electron microscopy demonstrated that the Nanosponges were spherical and porous. SEM images showed that the Nanosponges were spherical in all of their variations, but at larger ratios, drug crystals were visible on the surface of the nanosponge. An increase in the polymer concentration led to an increase in the drug/polymer ratio (1:1 to 1:3), which is growing in order. However, beyond a certain concentration, it was found that the particle size reduced as the drug-to-polymer ratio developed. All formulations have an average particle size that falls between 331.5 and 463.9 nm. The range of 82.21 to 97.78% was found for the drug content of various formulations. The drug release of the optimised formulation was found to be 94.92 % in 9 hours, while the entrapment efficiency of the other formulations ranged from 92.75 to 94.45%. According to stability experiments, the optimised gel formulation remained stable for a period of 15 days.