Dysmenorrhea, characterized by painful menstrual cramps, affects millions of women worldwide, impacting their quality of life and productivity. This study aimed to develop and evaluate a polyherbal cream for dysmenorrhea relief using natural herbal ingredients known for their analgesic and anti-inflammatory properties. The formulation consisted of ginger extract, cinnamon, fennel, borax, tween 80, mentha, and white beeswax. Each ingredient was selected based on its traditional use and scientific evidence supporting its efficacy in alleviating menstrual pain. The cream was prepared using a standardized method and evaluated for various parameters, including physical appearance, pH, viscosity, spreadability, and stability. Results showed that the polyherbal cream exhibited excellent physical characteristics, with a smooth texture, suitable pH, and optimal spreadability. In studies demonstrated significant anti-inflammatory activity, attributed to the synergistic effects of the herbal ingredients. Overall, the polyherbal cream showed promising potential as a natural remedy for dysmenorrhea, providing safe and effective relief from menstrual discomfort.[1]