This research investigates the role of indigenous languages in combating the spread of HIV/AIDS, focusing on Gombe State, Nigeria. Despite widespread efforts to educate the public about HIV/AIDS, language and communication barriers persist, hindering effective dissemination of preventive measures. Utilizing a descriptive study design, semi-structured interviews and questionnaires were employed to gather qualitative data from community members, healthcare providers, and local leaders. Statistical analysis revealed significant associations between demographic variables and awareness levels. Findings indicate that while participants demonstrated awareness of HIV/AIDS symptoms and prevention methods, gaps exist in understanding transmission routes, particularly oral transmission. Media, particularly local and international outlets broadcasting in indigenous languages, emerged as primary sources of information. The study highlights the importance of leveraging local languages in health communication to enhance awareness and preventive behaviors. Recommendations include expanding media campaigns in indigenous languages to curb HIV/AIDS transmission within Gombe State.