The pomegranate fruits (Punica granatum) outer skin is the source of pomegranate peel extract (PPE). Thanks to its scientifically proven antibacterial, antioxidant, anticancer, antiulcer, and anti-inflammatory qualities, this extract has become more and more popular. This review concentrates on PPEs antibacterial efficacy against viruses, fungi, bacteria, and parasites that are resistant to many drugs. The serial dilution method and the cup plate method were used to test PSEs antibacterial activity. According to the findings, PPE exhibits a broad range of antibacterial properties against a variety of microorganisms, such as viruses (S. aureus, E. coli, K. pneumoniae, Salmonella, Salmonella enterica, P. aeruginosa, S. marcescens, Brucella spp., and R. glutinis), fungi, and mold (F. sambucinum, P. digitatum, Saccharomyces cerevisiae, Monilinialaxa, M. fructigena,B. coagulans, B. cereus, and B. subtilis).