The demand for natural and herbal-based skincare products has been on the rise due to concerns over synthetic ingredients and their potential side effects. This study aimed to formulate and evaluate a herbal cream using the antimicrobial properties of the methanol extract of Tamarindus indica seeds. The methanol extract of Tamarindus indica seeds was obtained using standard extraction methods and incorporated into a cream base. Various physicochemical properties, including pH, viscosity, spreadability, and stability, were evaluated. The antimicrobial activity of the formulated cream was assessed against a range of pathogenic microorganisms using agar well diffusion and minimum inhibitory concentration (MIC) methods. The formulated herbal cream demonstrated satisfactory physicochemical properties, with a pH suitable for skin application and good spreadability. The cream exhibited significant antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as fungi. The MIC values indicated the potent antimicrobial efficacy of the Tamarindus indica seed extract in the cream formulation.