A significant amount of research has been done recently to find medications that can effectively treat the coronavirus illness 2019 (COVID-19). New approaches to enhancing the sufficiency of these medications were sparked by the uncertainty around the use of chloroquine to treat this sickness. Significant attention has been paid to the efficient use of zinc complexes as an adjuvant to chloroquine in the treatment of COVID-19. Density functional theory (DFT) was used to examine molecule electrostatic potential, electrical characteristics, and geometries at the 6LU7.This work studied the interaction of quinoline-based antimalarial drugs with the peptidase domain of ACE2 receptor. The X-ray crystal structure of human ACE2 receptor was downloaded from Protein Data Bank