Topical spray are dosage forms in which polymeric solution of drug is sprayed over the intact skin so as to get a sustained release of pain from polymeric matrix. Some natural substances of plant origin have good antimicrobial properties and have been used as antimicrobial agent. The aims of present investigation were to assay antibacterial properties of crude extract of cinnamon stick and clove. Clove are rich in phenolic compound mainly eugenol which exhibit antioxidant, anti-inflammatory, antimicrobial, antifungal and wound healing properties. Topical film forming antiseptic spray of clove and cinnamon were developed for antiseptic application.