Depression is a prevalent mental health disorder with significant public health implications, often resistant to conventional drug treatments. This paper explores the formulation and pharmacology of an herbal churna aimed at addressing depression using fenugreek seeds, ashwagandha, Brahmi, turmeric, and black pepper. These ingredients are selected based on their known antidepressant and anxiolytic properties, supported by their chemical constituents. The formulation process involves gathering, cleaning, drying, grinding, and mixing the ingredients in specific quantities. Pharmacologically, the churna leverages the antidepressant effects of compounds like 4-hydroxyisoleucine, withanolides, bacosides, and curcumin. The addition of black pepper enhances bioavailability. Evaluation tests such as organoleptic assessment, loss on drying, and ash value determination ensure quality and authenticity. This herbal churna presents a promising natural approach to managing depression, offering potential benefits for mental health and overall well-being.