The main motive of this work was to make serum using different herbal extract. The maim active ingredient in this formulation is guava leaves (P. guajava L., Myrtaceae) and other ingredient is aloe vera gel, glycerin, and coconut oil , rose water. Traditionally this plant is often in India, south America, Africa and other countries. It is used as food and traditional medicine in ancient time. The face serum are highly concentrated cosmetic products.3 Serum has a quick absorption and ability to penetrate deep layers of the skin, as well as a non-oily Finish and a deep formula with a very high amount of active ingredients. Due to deep penetration it’s give maximum pharmacological action. (4) Guava leaf was used as an outcome of the anti-wrinkle and whitening ability It also has Anti-oxidant properties that can prevent premature aging. Aloe vera gel is commonly used to treat various skin ailments, sunburn, Minor cuts, insect bites, and is also used as a wound healing, anti-inflammatory, anti-bacterial, and anti- Fungal effect. Olive oil has anti-inflammatory properties and is used as a skin moisturizing agent. The present study focused on the formulation of polyherbal face serum and evaluates the antioxidant property of serum. Antioxidants help protect skin cells from damage and aging and improve skin texture and appearance. Serum was formulated using various excipients like olive oil, sandalwood oil, glycerin, coconut oil, tween 20, dematerialized water. (5) According to the Food Drug Administration (FDA), cosmetics are substances or preparations intended for contact with external Cosmetics have a function, namely to clean the skin, beautify, increase attractiveness and change the appearance or maintain it in good condition of skin. The facial Serum was evaluated by its PH, physical appearance, spreadability, viscosity, microbial testing, cyclic temperature test Etc. The results of the stability study show that there was no change in visual acuity or homogeneity. (5)