stdClass Object
(
    [id] => 13516
    [paper_index] => 202406-02-017587
    [title] => REVIEW ON HPLC-UV METHOD TO DETERMINE CIMETIDINE,RANITIDINE, FAMOTIDINE AND NIZATIDINE IN URINE
    [description] => 
    [author] => Alfisha A. Maniyar, Dr. Sunil Jaybhaye, Khambayatkar Shruti M 
    [googlescholar] => 
    [doi] => 
    [year] => 2024
    [month] => June
    [volume] => 9
    [issue] => 6
    [file] => fm/jpanel/upload/2024/July/202406-02-017587.pdf
    [abstract] => A validated, uncomplicated, and widely applicable HPLC-UV technique for quantifying cimetidine, famotidine, nizatidine, and ranitidine in human urine is elucidated. This represents the inaugural singular HPLC method documented for scrutinizing all four H2 antagonists in human biological specimens. Furthermore, this technique was employed for assessing ranitidine and its byproducts in human urine. All calibration plots exhibited strong linear correlation (r 2 > 0.9960) across the experimental ranges. The methodology demonstrated commendable precision and accuracy, manifesting overall intra- and inter-day fluctuations of 0.2–13.6% and 0.2–12.1%, respectively. The separation of ranitidine and its metabolites through this analysis notably enhanced resolution, precision, and accuracy in comparison to prior methodologies. Subsequently, the analysis was effectively implemented in a human volunteer investigation utilizing ranitidine as the prototype compound.
    [keywords] => such as H2 antagonists, High performance liquid chromatography, Bioavailability, Metabolism, Ranitidine, Famotidine, Cimetidine, and Nizatidine are commonly utilized in research studies within the field of pharmacology.
    [doj] => 2024-07-03
    [hit] => 
    [status] => 
    [award_status] => P
    [orderr] => 90
    [journal_id] => 2
    [googlesearch_link] => 
    [edit_on] => 
    [is_status] => 1
    [journalname] => EPRA International Journal of Research & Development (IJRD)
    [short_code] => IJSR
    [eissn] =>  2455-7838 (Online)
    [pissn] => - -
    [home_page_wrapper] => images/products_image/2-n.png
)
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