Visha, or poison, comes from plants, animals, and minerals.We require antidotes or antitoxic medications to offset the harmful effects that poisons have on our bodies.In our treatises, Charak Samhita, Sushruta Samhita, and Ashtanga Hridyam, Vishaghana medicines are listed as a means of arresting the poisonous effects. The antipoisonous properties of Manjishtha will be covered in this article.The availability of both single and multiple manjishtha formulations suggests that it is useful in treating various poisonings. Comprehensive research is conducted on all facets of Manjishtha, with a particular focus on detoxification. All logical references have been chosen, and requirements-based collection, correlation, and explanation have been completed. Manjishtha's medicinal uses are highlighted based on indications and detoxification; these are particularly well-described in Ayurvedic and contemporary texts. The idea is that it will eventuallydenaturize any poison by dissecting the pathophysiology of toxicity. If the illness falls under any category related to toxicity, it might be helpful.Many toxicological illnesses are treatable and preventableNowadays, it can be widelyapplied for both curative and preventive purposes to ensure a life free from toxicological agents and disease, based on the concept of Vishaghana qualities of Manjishtha.