Today the focus is on reducing the likelihood of creating a potentially hazardous substance by concentrating on the synthesis of derivatives from approved medications. Non-steroidal anti-inflammatory medicines (NSAIDs) are a popular class of medications used to treat painful arthritis. The medication piroxicam is a non-steroidal anti-inflammatory. Piroxicam has been the basis for the synthesis of several derivatives with various biological activity in recent years. This mini review aims to describe the biological activities of these derivatives that have emerged in the previous ten years.