When studying the effects of medications, it is common to overlook their direct interaction with the cell membrane. The natural membrane's intricacy makes systematic research difficult, but model membrane systems can provide a helpful substitute. Here, a few instances of how drug molecules can be investigated for their effects on the membrane structure and their potential effects on embedded membrane proteins are reviewed using model membrane architectures such as vesicles, solid supported membranes, and Langmuir.The creation of new drugs depends heavily on a deeper understanding of the molecular mechanisms behind drug-membrane interactions. Various biochemical and biophysical techniques have been established thus far to investigate biological membranes at the molecular level. This review centers on the accomplishments and new uses of contemporary analytical methods, such as spectrometry, calorimetry, acoustic sensing, and chromatography, in the investigation of drug interactions with lipid membranes. These methods' advantages and disadvantages were contrasted and thoroughly examined. Furthermore, a number of biomimetic model membrane types were described, such as liposomes, lipid monolayers, and supported lipid monolayers/bilayers. A brief introduction to the general mechanics behind the drug-membrane interaction process was also provided.