A deeper understanding of the molecular mechanisms behind medicine- membrane relations are pivotal for the development of new drugs. To date, a number of biochemical and biophysical styles have been developed to study natural membranes at the molecular position. This review focuses on the advancements and new operations of ultramodern logical ways, including spectrometry, calorimetry, aural seeing, and chromatography, in the study of medicine relations with lipid membranes. The benefits and downsides of these approaches were compared and precisely considered. also, several biomimetic model membrane types, including liposomes, lipid monolayers, and supported lipid monolayers bilayer, were described. also, a brief overview of the general mechanics underpinning the medicine- membrane commerce process was given.