Depression, a pervasive mental health disorder, significantly impacts the quality of life and well-being of individuals worldwide. While conventional pharmacological treatments are effective for many, they often come with side effects and limitations. Ayurveda, the traditional Indian system of medicine, offers holistic approaches that focus on balancing the mind, body, and spirit. This review explores Ayurvedic interventions for depression, including the use of herbal medicines, dietary modifications, lifestyle practices, and Panchakarma therapies. We also examine the underlying principles of Ayurveda related to mental health and the potential mechanisms through which these treatments may exert their effects. Depression is a widespread mental health disorder affecting millions of people globally. Characterized by persistent sadness, lack of interest in daily activities, and a variety of physical and emotional problems, depression can severely impact an individual's quality of life. While conventional medicine offers a range of treatments, including antidepressants and psychotherapy, there is a growing interest in alternative and holistic approaches. Among these, Ayurveda, an ancient Indian system of medicine, has gained attention for its potential in treating depression.