Around the world, garlic (Allium sativum L.) is a bulbous herb that is utilized as a food, spice, and medicinal. The traditional knowledge that has been passed down from generation to generation informs its medical application. These days, scientists from a variety of fields are focusing their research on learning more about how garlic affects human health. Researchers' interest in garlic has been sparked by the need to find a medication with a wide therapeutic range and low toxicity, especially among medical professionals. According to recent research, garlic extract exhibits antimicrobial action against a wide variety of virus, fungus, and bacteria types. Many writers have praised the benefit of garlic in reducing cardiovascular disease. Studies on the chemical components of garlic have been conducted to treat hypertension, hyperlipidemia, and platelet aggregation.Many disorders, including antidiabetic, antioxidant, anti-inflammatory, hepatoprotective, antihelmentic, antibacterial, antiviral, antifungal, and wound healing, have been treated using garlic and its constituents. Alzheimer's disease, cancer, cardiovascular disease (including atherosclerosis, hypertension, thrombosis, and hyperlipidemias), dermatological conditions, stress, and infections are among the illnesses that garlic's therapeutic properties may help reduce. This article's goal is to provide an overview of the pharmacological properties, traditional use, and active ingredients of garlic. It may also be utilized as a likely natural source for the development of novel medications.