The development of polyherbal transdermal patches offers a novel approach to delivering therapeutic agents for managing fever (antipyretic) and pain (analgesic). This study focuses on formulating and evaluating a polyherbal transdermal patch using natural plant extracts with proven antipyretic and analgesic properties. Key ingredients include herbal extracts like Azadirachta indica (Neem), Curcuma longa (Turmeric), and Zingiber officinale (Ginger), chosen for their synergistic pharmacological effects. The transdermal patch is designed to ensure sustained release of active compounds through the skin, enhancing bioavailability and reducing gastrointestinal side effects associated with oral administration. The patches were prepared using a solvent casting method, employing biocompatible polymers such as hydroxypropyl methylcellulose (HPMC) and ethyl cellulose for controlled drug release. The formulations were evaluated for physicochemical properties, including thickness, weight uniformity, tensile strength, drug content, and in-vitro release profile. Ex-vivo skin permeation studies and in-vivo antipyretic and analgesic efficacy were conducted to assess the therapeutic potential of the patches.