Cassia angustifolia, a member of the Fabaceae family, is known for its traditional medicinal value in treating various illnesses caused by pathogens. This study aims to evaluate the phytochemical properties and in vitro antimicrobial activity of Cassia angustifolia extracts, ranging from non-polar to polar solvents. Results indicate that the extracts contain significant amounts of secondary metabolites, with methanol proving to be the most effective solvent for extracting these compounds. All extracts contain detectable levels of phenols and flavonoids, with methanol extracts showing the highest concentrations, followed by water, acetone, and hexane extracts. The extracts also exhibit antimicrobial activity against various pathogenic bacteria and fungi, with methanol extract displaying the strongest effect, followed by water, acetone, and hexane extracts. Further research is recommended to enhance the development of plant-based drugs from Cassia angustifolia.