Beginning with the commencement of irregular menstruation or missing periods and ending 12 months after the last menstrual period, this phase marks the shift from active reproduction to the cessation of considerable estrogen release due to the depletion of functioning ovarian follicles. Menopause is connected with alterations typical of cardiovascular aging. Cardiac disease has a wide range of impacts, including alterations in endothelial function, coronary artery physiology, and metabolic dysfunction, all of which lead to structural abnormalities in coronary morphology. Atherosclerosis is the leading cause of death. In earlier cross-sectional investigations, we discovered a significant incidence of metabolic cardiovascular risk factors in women before and after menopause, and we identified the menopausal transition as a key period for atherosclerosis acceleration. In the current longitudinal study, we evaluated changes in the primary cardiovascular risk variables in women after the transition to menopause.