Cissus quadrangularis, a medicinal plant belonging to the family Vitaceae, has been used traditionally for its therapeutic properties in various cultures, particularly in Africa, India, and Southeast Asia. Known for its anti-inflammatory, analgesic, antioxidant, and antimicrobial activities, C. quadrangularis is widely employed in treating fractures, joint disorders, and bone health-related issues. It contains bioactive compounds, such as flavonoids, alkaloids, and phenolic acids, which contribute to its wide range of pharmacological effects. Studies suggest that C. quadrangularis may enhance bone healing, promote collagen synthesis, and reduce pain associated with bone fractures. In addition, it is being investigated for its potential in managing metabolic disorders like obesity and diabetes due to its ability to regulate blood glucose and lipid profiles. Despite its promising benefits, further clinical studies are needed to validate its efficacy and safety for therapeutic use.