The immune system protects the body by detecting and eliminating foreign invaders, as well as identifying and rejecting ancient cells and aberrant endogenous organisms. Proteins that have misfolded or been degraded are considered cellular trash. As a result, the susceptible system may detect chemical and biological features with a spatial resolution of several nano meters. Molecular patterns found in a wide range of illnesses, such as viral and bacterial proteins and nucleic acid sequences. The susceptible system can either rejoice or pass nanoparticles undetected. Once honored, they can evoke a seditious or anti-inflammatory response. When nanoparticles enter the body, they virtually always interact with cells. The interactions between nanoparticles and immune cells may have a negative impact, increasing susceptibility to infectious infections, autoimmune disorders, and cancer. The nanoparticles Interact with various types of Immune cells such as Interaction of nanoparticles with monocytes/ macrophages, interaction of nanoparticles with Lymphocytes.