The study investigated the Anticarcinogenic effect of Gulguluthikthakam Kashayam and Emilia sonchifolia extract on tumor induced mice. The study focused on plants with antineoplastic and anti-cancer activity which are not scientifically evaluated. Invitro assays were conducted in hemolysate, liver, kidney & heart and statistical analysis were done for each. A significant decrease was observed in parameters like LDH, ALP, GPT, GOT, HMG CoA Reductase, GSSG, TBARS, Total proteins, Albumin, DNA, Total lipid, Phospholipid, Cholesterol, FFA, Total hexose, Fucose, Sialic acid, WBC and Catalase, G-PX, TG, Ascorbate, Clotting Time was found to be increased in drug treated groups compared to tumor control groups. The candidate drugs show anticarcinogenic activity.