Anemia is a common and complex complication that affects people who are infected with HIV/ AIDS, therefore thorough understanding of its processes and specialized care required. This study focuses anemia approaches are managing in HIV infected individuals through erythropoietin therapy EPO Therapy has surfaced and blood transfusions as a potentially effective treatment option for HIV as related anemia .This study also focuses on as it examines blood transfusions novel techniques and clinical issues for managing of HIV. This article anemia in the context summerizes existing information and and describes approaches for more management, from new successful anemia figuring out the complex interaction between HIV and anemia to weighing the advantages and disadvantages of erythropoietin Therapy and blood transfusions. The review discusses the difficulties in diagnosing patients, clinical recommen- dations and how anemia affects patient's quality of life. It als o explores novel iron stratergies , such as supplementation and erythropoietin emphasizing used to the context how they might be maximize erythropoiesis in of HIV.