An innovative way to medication distribution, transdermal patches provide a regulated, non-invasive, and patient-friendly substitute for conventional techniques. Transdermal patch technology is thoroughly reviewed in this article, which also examines its fundamental ideas, essential elements, and many medical treatment uses. Advances in adhesive and matrix technologies, the mechanics of medication absorption via the skin, and methods for overcoming obstacles such skin irritation and restricted permeability are among the topics discussed. Recent advancements including smart patches with real-time monitoring features and patches augmented by microneedles are also highlighted in the review. The potential of transdermal patches to transform healthcare delivery and open the door to more effective and individualized treatment solutions is highlighted in this article by discussing both the advantages and disadvantages of this technology.