In the present study Leflunomide solid dispersions were formulated. Leflunomide was mixed with variousproportions of excipients showed no colour change at the end of two months, proving nodrug-excipient interactions. The precompression blend of Leflunomide soild dispersions were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio. The precompression blend of all the batches indicating good to fair flowability and compressibility. Solid dispersions were prepared with various concentrations of carriers, theprepared solid dispersions were compressed into tablets by using rotary tablet punching machine, and 8 mm punch, with the hardness of 4.5kg /cm 2 .The formulated tablets were evaluated for various quality control parameters. The tablets were passed all the tests. Among all the formulations F1 formulation containing, Drug and Peg 4000 in the ratio of 1:0.25showed good result that is 94.95 % in 50 minutes. As the concentration of polymer increases the drug release was decreased. While the formulations containing PEG 6000 showed less release. Hence from the dissolution data it was evident that F1 formulation is the better formulation.