Background: Ayurveda consider Health and Disease both as the products of food and life style. Today when population is moving with modernization in the 21st century a lot of new diseases emerge out due to faulty life style, unhealthy food, lack of exercise, mental stress and disturb sleep. All these disturbs the biological clock of human being and produce new life style diseases. Ajirna is a common disease which originates from digestive power insufficiency (Agni) due to all above factors of modern Era. Ayurveda is the ancient Indian system of medicine, deals with management and prevention of disease. It has given prime importance to Agni, as it is one of the basic biological elements of the living body. It is having Its own physical characteristics, location, function and secretions like digestive juices and enzymes which participate in the digestion and metabolic functions. There are 4-6 types of Ajirna mentioned in Ayurveda by different acharyas. Also there is variation in treatment as per opinion of different acharyas. So it is important to see the details of Ajirna Chikitsa in Ayurved collectively. Preventive measures like Dincharya, Ratricharya, Ritucharya, Sadvrita, pathya bhojana Grahan are helpful to reduce the Ajirna Avastha in patient.So this article is focusing on the Ajirna (Indigestion) Chikitsa in Ayurveda. Materials and Methods: For the present study, 40 patients of Ajirna were randomly selected according to the Inclusion criteria. The prepared medicine was trailed in two groups (Groups A and B) each having 20 Patients. The assessment was in every 15 days of intervals. Discussion and Conclusion: Statistically, Placebo drugs provided no significant results and Vadabamukha Churna provided significant results in improving subjective and objective signs and symptoms of Ajirna.