Modern drug formulations have integrated excipients to serve a more active role unlike in the past when they were merely passive ingredients. A shift towards more herbal and natural alternatives has made the use of herbal excipients in novel drug delivery systems (NDDS) more feasible. These plant based materials, which include gums, mucilages, and resins, have biocompatibility and biodegradability properties, rendering them much safer than conventional drugs. Thus, they are ideal for advanced drug delivery systems which require more sophisticated approaches such as controlled release, targeted delivery, and even nanoparticles. This article describes the different kinds of NDDS herbs used as excipients and their benefits over man made ones. Moreover, this article highlights the effect of consistency, standardization, and regulations posed on herbal materials. Lastly, this review stresses the future importance of herbal excipients in drug delivery systems as it is beneficial for both the patient and the pharmaceutical companies.