Prameha is a group of disorders, which bear a resemblance to the modern understanding of Diabetes Mellitus. Prameha is further classified into Sthoola Pramehi (associated with obesity) and Krisha Pramehi (associated with leanness)5. According to Ayurveda2, Sthoola Pramehi results from the imbalance of Kapha and Meda (fat tissue) and the obstruction of normal body channels (Srotas) leading to insulin resistance, Krisha Pramehi 1(Lean Diabetic) on the other hand, is observed in individuals with a lean body constitution. This condition is associated with the imbalance of Vata and depletion of Dhatus (body tissues), leading to frequent urination, emaciation, and general weakness. Hence, to control those abnormalities an ayurvedic formulation, namely, “Nisha Triphala Yoga” 6was selected for the management of Sthoola Pramehi and Krisha Pramehi. Materials and Methods: For the present study, 30 patients of Prameha (15 Sthoola and 15 Krisha) were randomly selected according to the Inclusion criteria. The prepared medicine was trialed in two groups i.e. Groups A (Sthoola Pramehi) and Group B (Krisha Pramehi) each having 15 Patients. The assessment was in every 15 days of intervals for one month. Discussion and Conclusion: Statistically, Nisha Triphala Yoga provided more significant results in Group A than Group B by improving subjective and objective signs and symptoms of Prameha