The most practical and easiest way to administer medication is orally. the most economical and dominant in the global drug delivery industry are oral medication delivery systems. Low and irregular bioavailability, primarily due to inadequate water solubility, is the main issue with oral medication formulations. High levels of variability between and between subjects, a lack of dose proportionality, and treatment failure could result from this. According to estimates, 40% of active ingredients are inherently water insoluble or weakly soluble in water. Enhancing the bioavailability of medications possessing such attributes is a formidable task in drug formulation. The literature reports on a number of technological approaches, such as solid dispersions, the production of cyclodextrine complexes or micronization, and other drug delivery system technologies. With these methods included, self-emulsifying drug delivery systems (SEDDS) have drawn increased interest in order to improve oral bioavailability while lowering dosage. Isotropic blends of oil, surfactants, solvents, and co-solvents/surfactants are known as SEDDS. The main feature of these systems is their capacity to dilute by an aqueous phase and then, upon gentle agitation, form fine oil-in-water (o/w) emulsions or microemulsions. SEDDS could be a useful tactic to increase the pace and extent of oral absorption for lipophilic medications, whose absorption is limited by their dissolution rate. This review article describes how poorly soluble drugs can become more soluble and more bioavailable through the use of self-emulsifying drug delivery devices.