The misuse of prescription and over-the-counter (OTC) drugs has emerged as a significant public health concern, contributing to addiction, adverse health outcomes, and increased healthcare costs. Commonly misused medications include opioids, stimulants, sedatives, and certain OTC drugs such as cough syrups and decongestants. Pharmacists, as accessible healthcare professionals, are uniquely positioned to combat this growing issue. Their role in preventing drug misuse includes patient education, prescription monitoring, identifying potential abuse patterns, and collaborating with healthcare providers. By implementing stricter dispensing practices, utilizing Prescription Drug Monitoring Programs (PDMPs), and counseling patients on the proper use and risks of medications, pharmacists can play a critical role in reducing drug misuse and promoting safer medication practices. Strengthening the pharmacist's role through training and policy support is essential in addressing this widespread problem.