Transdermal drug delivery systems are used to apply medications topically.(1) A transdermal patch is an adhesive patch with a medication (drug) covering that is applied to the skin to gradually release a predetermined dosage of the medication (drug) into the bloodstream. [2].A temperature variation of 37 ± 1°C was used to dissolve the patch in phosphate buffer (pH 7.4).During the manufactured transdermal patch's in vitro penetration research, a time- dependent increase in drug release was observed.The transdermal patch was created using the solvent casting process, and using scanning electron microscopy (SEM), it was assessed for organoleptic distinctiveness, stratification, weight consistency, flipping fortitude, dampness content, drug content, and external appearance. The Franz diffusion cell was used to perform in-vitro release kinetics, and the egg's outer membrane served as a barrier membrane.[3]