This study focuses on formulating and evaluating an eco-friendly herbal handwash powder using natural ingredients like Reetha, hibiscus flower, Cestrum nocturnum. The powder handwash is designed to provide effective hand hygiene while minimizing environmental impact. The formulation is evaluated for physicochemical properties, antimicrobial activity, skin compatibility, and environmental safety. The results show that the herbal handwash powder exhibits significant antimicrobial activity, is gentle on skin, and is biodegradable. This eco-friendly handwash powder offers a sustainable alternative to conventional handwashing products, promoting environmental sustainability and natural health.