In this formulation some available chemicals and natural ingredient were used which has no harmful effect to human skin. Chemicals that used were Carbopol 934, sodium benzoate, glycerin, tri-ethanolamine and natural ingredient is aloe & Strawberry Extract. Aloe vera extract which shows effective activity against allergic, irritation and inflammation problem due to its synergistic property. Firstly, aloe gel was extracted by ethanol extraction. Gel was formulated combining all ingredients. To justify the effectiveness of any formulation, results of evaluation tests are very important. For this, necessary physicochemical properties such as appearance, transparency, consistency, homogeneity, pH, thermal stability, conductivity, spreadability, viscosity etc. were evaluated. The results were satisfactory. No microbial growth was found during the incubation period for the prepared ultrasound gel. Also, no adverse effect to the human skin like irritation, allergy, inflammation etc. was observed. Ultrasound gel usually acts as a conductive medium and the conductivity result provides the information about the image quality. Conductivity of this formulated gel was 4.05 µS/cm. Using this formulated ultrasound gel during ultrasonography, clear image was found which was also of good quality. The overall results suggest that this formulation can be considered as successful and used with no harmful effect compared to the synthetic ones. The present study focuses on the formulation and evaluation of an ultrasound-assisted polyherbal gel designed for enhanced transdermal delivery and therapeutic efficacy. Utilizing the synergistic properties of selected medicinal plants, the polyherbal formulation incorporates extracts known for their anti-inflammatory, antimicrobial, and wound-healing properties. Ultrasound (sonophoresis) was employed to improve the penetration of phytoconstituents through the skin barrier, thereby optimizing bioavailability and therapeutic action. The gel was formulated using biocompatible polymers and characterized for its physicochemical properties including pH, viscosity, spreadability, and stability. In vitro and ex vivo studies demonstrated enhanced permeation and sustained release of active constituents when ultrasound was applied, compared to conventional topical application. The results indicate that ultrasound-assisted delivery significantly enhances the effectiveness of the polyherbal gel, making it a promising candidate for the treatment of various dermatological conditions.