Timely detection and treatment of chronic hypertrophic laryngitis is of particular importance and is a key link in the prevention of malignant tumors of the larynx. Traditional diagnostic methods do not always allow for a correct assessment of the condition of the larynx in chronic laryngitis and the dynamics of recovery processes during treatment. Therefore, the combined use of modern methods for examining the larynx is of great importance. Based on such a study of 14 men and 6 women aged 20 to 63 years, who were treated for chronic hypertrophic laryngitis, it was shown that videostroboscopy, autofluorescent diagnostics, NBI-endoscopy, and cytological examination of smears from the affected areas of the vocal folds are methods of early diagnosis of chronic hyperplastic laryngitis, which can complement each other not only when making diagnosis difficult, but also when assessing the effectiveness of treatment and rehabilitation measures aimed at restoring the functions of the larynx and preventing the development of tumors. The obtained data made it possible to clarify the nature of hypertrophic changes in the mucous membrane of the vocal folds and reliably interpret the clinical picture of the disease in the examined patients as a manifestation of chronic hyperplastic laryngitis with signs of leukkeratosis and leukoplakia.