Oral health is a vital aspect of general well-being, yet conditions such as mouth ulcers and microbial infections continue to affect a large portion of the population. The current study explores the formulation and evaluation of polyherbal chewable tablets using Piper betle (betel leaf) as a primary active ingredient, known for its antimicrobial, anti-inflammatory, and healing properties. Complementary herbal components such as betel leaf, licorice root & jasminium officinale, guava were incorporated to enhance the formulation’s efficacy. The tablets were developed using standard wet granulation techniques and assessed for various pharmaceutical parameters including hardness, disintegration time, taste masking, and stability. In vitro antibacterial testing demonstrated significant inhibitory effects against common oral pathogens including Streptococcus mutans and Candida albicans. Preliminary clinical observations indicated reduced incidence and faster healing of mouth ulcers with regular use.This study supports the potential of betel leaf-based polyherbal chewable tablets as a natural, safe, and effective solution for maintaining oral hygiene and preventing common oral conditions. Further research and clinical trials are recommended to establish long-term efficacy and consumer acceptance.