Herbal remedies has safe and natural alternatives for managing cough. This study focuses on the formulation and evaluation of an herbal cough syrup derived from Anacyclus pyrethrum (Akarkara), known for its therapeutic effects. Using a standardized extraction process, the syrup was prepared with carefully selected excipients to optimize stability, viscosity, pH, and palatability. Physicochemical analyses confirmed that the syrup met acceptable standards for density, viscosity, pH, and organoleptic properties. Qualitative analysis identified key bioactive compounds, including polyacetylenes and alkylamides, responsible for its pharmacological effects. In vitro studies demonstrated the syrup’s expectorant, bronchodilator, and anti-inflammatory activities, supporting its efficacy in alleviating cough symptoms. Stability testing further validated the product’s shelf-life under recommended storage conditions. Sensory evaluation by volunteers revealed high acceptability in terms of flavor, texture, and ease of use. Overall, the formulated Anacyclus pyrethrum herbal cough syrup exhibits promising potential as a safe, effective, and patient-friendly treatment for cough. However, further clinical investigations are required to confirm its therapeutic benefits and establish its role in respiratory healthcare.