Atopic Dermatitis, commonly known as eczema, is a common chronic, relapsing skin disease characterized by pruritus, disrupted epidermal barrier function, and immunoglobulin e- mediated sensitization to food and environmental allergens. AD is often called the “itch that rashes” because the itching starts, and then the skin rash follows as a result of scratching. This eczema can cause two types of pigmentation changes that are, Hypopigmentation and Hyperpigmentation. Eczema is a complex disease that arises from interaction between genes and environment. There are 3 classical stages of eczema: infantile, childhood, 1and adulthood. Eczema is a type of condition that causes skin inflammation. Therefore, topical preparations are at core of eczema treatment; these includes topical moisturizers, topical corticosteroids, and topical calcineurin inhibitors. However, even with careful treatment, eczema is likely to relapse.