Folic acid, an BCS class IV essential nutrient, having low solubility and permeability, limiting its bioavailability and therapeutic efficiency. This study aims to enhance folic acid solubility and permeability through solid dispersion and inclusion complex formation utilizing Gelucire 50/13 and hydroxypropyl-beta-cyclodextrin. Solid dispersions of folic acid with Gelucire 50/13 (1:4 ratios) increased solubility by 8.5 fold, respectively. Using HP-β-CD to create inclusion complexes increased permeability by 20-30 fold. These data illustrate the potential of this combination method to considerably increase folic acid solubility and permeability.These results show that this combined method has the potential to greatly improve folic acid solubility and permeability, hence increasing its bioavailability and therapeutic potential.